pix-1 Controls Early Elongation in Parallel with mel-11 and let-502 in Caenorhabditis elegans
نویسندگان
چکیده
منابع مشابه
pix-1 Controls Early Elongation in Parallel with mel-11 and let-502 in Caenorhabditis elegans
Cell shape changes are crucial for metazoan development. During Caenorhabditis elegans embryogenesis, epidermal cell shape changes transform ovoid embryos into vermiform larvae. This process is divided into two phases: early and late elongation. Early elongation involves the contraction of filamentous actin bundles by phosphorylated non-muscle myosin in a subset of epidermal (hypodermal) cells....
متن کاملRho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo.
Rho-binding kinase and myosin phosphatase regulate the contraction of actomyosin filaments in non-muscle and smooth muscle cells. Previously, we described the role of C. elegans genes encoding Rho-binding kinase (let-502) and myosin phosphatase targeting subunit (mel-11) in epidermal cell-shape changes that drive morphogenesis and in spermathecal contraction. Here we analyze their roles in a th...
متن کاملEmbryonic morphogenesis in Caenorhabditis elegans integrates the activity of LET-502 Rho-binding kinase, MEL-11 myosin phosphatase, DAF-2 insulin receptor and FEM-2 PP2c phosphatase.
let-502 rho-binding kinase and mel-11 myosin phosphatase regulate Caenorhabditis elegans embryonic morphogenesis. Genetic analysis presented here establishes the following modes of let-502 action: (i) loss of only maternal let-502 results in abnormal early cleavages, (ii) loss of both zygotic and maternal let-502 causes elongation defects, and (iii) loss of only zygotic let-502 results in steri...
متن کامل03-P014 Myosin II regulation during embryonic elongation in C. elegans: LET-502/ROCK, PAK-1 and MRCK-1, three kinases with different roles
lar interactions and their local environment. Cell traction force microscopy (CTFM) was utilised to determine the exerted traction forces of individual cells on a coated elastic substrate. From knowledge of the elasticity of the gel (Young’s modulus) the displacement of the gel surface was used to calculate traction fields using finite element analysis (FEA). This initial data are being refined...
متن کاملThe let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans.
During induction of the Caenorhabditis elegans hermaphrodite vulva by the anchor cell of the gonad, six multipotent vulval precursor cells (VPCs) have two distinct fates: three VPCs generate the vulva and the other three VPCs generate nonspecialized hypodermis. Genes that control the fates of the VPCs in response to the anchor cell signal are defined by mutations that cause all six VPCs to gene...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0094684